Explore South San Francisco local geography, civic resources and voter guides, with dated official population and registration facts for San Mateo County.
At a glance: South San Francisco is an incorporated city in San Mateo County. Population: 65,239 (California Department of Finance estimate as of January 1, 2026). Registered voters: 38,485 (California Secretary of State, as of September 4, 2026).
South San Francisco occupies the northern Peninsula between San Bruno Mountain and the Bay. Downtown Grand Avenue, hillside neighborhoods and the biotechnology-oriented area east of US 101 give the city a character distinct from San Francisco itself. The Library | Parks and Recreation Center at 901 Civic Campus Way combines library and recreation functions beside a park connected to Centennial Way Trail. Orange Memorial Park supplies another major setting for sports and outdoor community life. South San Francisco incorporated on September 19, 1908. It is a general-law city with a council-manager government and is not a district of San Francisco. The date is recorded in the county's municipal profile.
No. It is an independent city in San Mateo County.
The Library | Parks and Recreation Center is at 901 Civic Campus Way. Different spaces can have different operating hours.
San Mateo County elections provides registration, ballot and voting-location information.
38,485 (California Secretary of State, as of September 4, 2026).
CA Slates began with shared voter guides in 2012 and expanded into its current publication family and connected program.